P-gp inhibitor 5
Product Specifications
CAS Number
2451298-06-7
Target
Others|||P-gp
Related Pathways
Membrane transporter/Ion channel|||Others|||Neuroscience
Bioactivity
P-gp inhibitor 5 is a potent P-glycoprotein (P-gp) inhibitor, reducing P-gp activity by a factor of 2.5 and 3.0 at 1.25 ?M and 2.5 ?M, respectively. It exhibits anti-proliferative effects on certain cancer cells and restores cellular sensitivity to Vincristine and Paclitaxel, reversing the multidrug resistant (MDR) phenotype of ABCB1/Flp-InTM-293 and KBvin.
Smiles
O(C(C)=O)C1=C2C(=C(NC(=O)C3=C(Cl)C=CC=C3)OC2=CC(=C1)C4=CC=C(OC)C=C4)C5=CC=CS5
Molecular Formula
C28H20ClNO5S
Molecular Weight
517.98
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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