IRAK4-IN-22
Product Specifications
CAS Number
2170694-05-8
Target
Others, IRAK
Related Pathways
Others, NF-κB, Immunology/Inflammation
Bioactivity
IRAK4-IN-22 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 3 nM) and TAK1 (IC50: 17 nM) . IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.10 μM. IRAK4-IN-21 can be used to study autoimmune diseases, such as plaque psoriasis and psoriatic arthritis.
Smiles
N([C@@H]1[C@@]2(C[C@]([C@@H]1C(N)=O)(C=C2)[H])[H])C=3C(=CN=C(NC4=CC(C(=O)N5CCCC5)=CC=C4)N3)C=6C=C(F)N=CC6
Molecular Formula
C28H28FN7O2
Molecular Weight
513.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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