EGFR/HER2/TS-IN-2
Product Specifications
CAS Number
2444364-04-7
Target
Others|||DNA/RNA Synthesis|||EGFR
Related Pathways
Others|||Angiogenesis|||Tyrosine Kinase/Adaptors|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||JAK/STAT signaling
Bioactivity
EGFR/HER2/TS-IN-2 is a potent inhibitor of EGFR (IC50: 0.173 ?M), HER2 (IC50: 0.125 ?M) and TS (IC50: 1.12 ?M) . EGFR/HER2/TS-IN-2 exhibited cytotoxic effects on MDA-MB-231 cancer cells (IC50: 1.69 ?M) .
Smiles
C(#N)C=1C(=NC(SCC(NC=2SC=3C(N2)=CC=C(C)C3)=O)=NC1C4=CC=CC=C4)N5N=C(C)C=C5C
Molecular Formula
C26H21N7OS2
Molecular Weight
511.62
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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