HDAC/HSP90-IN-3
Product Specifications
CAS Number
2700035-54-5
Target
HSP|||Others|||Antifungal|||HDAC
Related Pathways
Chromatin/Epigenetic|||Others|||DNA Damage/DNA Repair|||Microbiology/Virology|||Metabolism|||Cytoskeletal Signaling
Bioactivity
HDAC/HSP90-IN-3 is a selective and potent dual inhibitor of fungal Hsp90 (IC50: 0.83 ?M) and HDAC (IC50: 0.91 ?M), exhibiting antifungal effects against azole-resistant Candida albicans. HDAC/HSP90-IN-3 exhibits inhibitory effects on important virulence factors and is able to downregulate the resistance genes ERG11 and CDR1.
Smiles
O=C1N(C(=NN1)C2=CC(C(C)C)=C(O)C=C2O)C3=CC=C(C(NCCCCCCCC(NO)=O)=O)C=C3
Molecular Formula
C26H33N5O6
Molecular Weight
511.57
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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