Bcl-2-IN-7
Product Specifications
Target
Caspase, Apoptosis, Bcl-2 Family, MDM-2/p53, Others
Related Pathways
Others, Proteases/Proteasome, Apoptosis
Bioactivity
Bcl-2-IN-7 is a potent inhibitor of Bcl-2 (b-cell lymphoma-2), which can downregulate the expression of Bcl-2, increase the expression of p53, Bax, caspase-7 mRNA, and induce cell cycle arrest and apoptosis in MCF-7 cells of breast cancer. Bcl2-IN-7 showed good antitumor activity against MCF-7 cells (IC50: 20.17 μM), LoVo cells (IC50: 22.64 μM), HepG2 cells (IC50: 45.57 μM) and A549 cells (IC50: 51.50 μM) .
Molecular Formula
C24H22N4O5S2
Molecular Weight
510.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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