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NRX-252114

Product Specifications

CAS Number

2763260-39-3

Target

Molecular Glues, Wnt/beta-catenin

Related Pathways

PROTAC, Stem Cells, Cytoskeletal Signaling

Purity

0.997

Bioactivity

NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, and is able to enhance the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. Kd is 0.4 nM.

Smiles

S(C1=C(C(=O)N2CC=3C(C2)=CC=CC3C#N)C(=O)NC(C(F)(F)F)=C1)C4=C(Cl)C=CC=C4Cl

Molecular Formula

C22H12Cl2F3N3O2S

Molecular Weight

510.32

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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