Top/HDAC-IN-1
Product Specifications
Target
Apoptosis, Others, Topoisomerase, HDAC
Related Pathways
DNA Damage/DNA Repair, Others, Apoptosis, Chromatin/Epigenetic
Bioactivity
Top/HDAC-IN-1 is a dual topoisomerase (Top) /HDAC inhibitor that acts on HDAC1 (IC50: 18 nM), HDAC2 (IC50: 230 nM), HDAC3 (IC50: 790 nM), HDAC6 (IC50: 87 nM) and HDAC8 (IC50: 5250 nM) . Top/HDAC-IN-1 exhibited potent antitumor effects on HCT116 cells (IC50: 180 nM), blocked the cell cycle of HCT116 cells in G2 phase, and effectively induced apoptosis.
Molecular Formula
C29H27N5O4
Molecular Weight
509.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
RAF-451-1 1 mL
TRITC Conjugated Goat Affinity Purified Antibody to Rabbit IgG, Fc Specific
Sign In for Pricing
View Details 
BNC400736-500 1x 500 µL
Neurofilament (NF-L) (NFL/736), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
TRC-D925210-100MG 100 mg
6-(Dibutylamino)-1,3,5-triazine-2,4(1H,3H)-dione
Sign In for Pricing
View Details 