BI-1622
Product Specifications
CAS Number
2681392-19-6
Target
Others|||BTK|||PI4K|||JAK|||EGFR|||Raf|||CDK|||Tyrosine Kinases
Related Pathways
Chromatin/Epigenetic|||JAK/STAT signaling|||MAPK|||Stem Cells|||Tyrosine Kinase/Adaptors|||PI3K/Akt/mTOR signaling|||Cell Cycle/Checkpoint|||Others|||Angiogenesis
Bioactivity
BI-1622 is a highly selective, orally active HER2 (ERBB2) inhibitor (IC50: 7 nM) . BI-1622 is >25-fold selective for EGFR. In a mouse model of transplanted tumors transfected with H2170 and PC9 cells, BI-1622 exhibited high in vivo antitumor effects with good drug metabolism and pharmacokinetic properties.
Smiles
N(C=1C2=C(C=NC(=N2)N3CCN(C(C=C)=O)CC3)N=CN1)C4=CC(C)=C(OC5=CC=6N(C=C5)N=CN6)C=C4
Molecular Formula
C26H24N10O2
Molecular Weight
508.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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