RET-IN-14
Product Specifications
CAS Number
2755843-62-8
Target
C-RET|||BTK|||Others
Related Pathways
Apoptosis|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Others
Bioactivity
RET-IN-14 is a potent inhibitor of RET, capable of acting on RET (WT) (IC50 < 0.51 nM), RET (G810R) (IC50: 9.3 nM), RET (V804M) (IC50: 1.3 nM), BTK (C481S) (IC50: 9.2 nM) and BTK (C481S) (IC50 : 15 nM) . RET-IN-14 exhibits potential for tumor studies.
Smiles
NC=1N2C3=C(C=N2)C(=O)NC[C@H](C)OC=4C(CN=C(N3)C1C5=CC=C(NC(OC)=O)C=C5)=CC(F)=CN4
Molecular Formula
C24H23FN8O4
Molecular Weight
506.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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