NAZ2329
Product Specifications
CAS Number
2809469-05-2
Target
Others|||Phosphatase
Related Pathways
Metabolism|||Others
Bioactivity
NAZ2329 is the first cell-permeable inhibitor of the R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), which is a variant and preferentially inhibits PTPRZ (IC50=7.5 ?M for hPTPRZ1) and PTPRG (IC50=4.8 ?M for hPTPRG) compared to other PTPs. NAZ2329 inhibited the tumor growth of glioblastoma cells and exhibited stem cell-like properties compared to the whole (D1 + D2) fragment of PTPRZ.
Smiles
S(CC1=C(OCC)C=CC(C(F)(F)F)=C1)C2=C(C(NS(=O)(=O)C3=CC=CC=C3)=O)SC=C2
Molecular Formula
C21H18F3NO4S3
Molecular Weight
501.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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