PHA-680632

Product Specifications

CAS Number

398493-79-3

Target

FGFR|||PLK|||Aurora Kinase

Related Pathways

Chromatin/Epigenetic|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Cell Cycle/Checkpoint

Purity

0.9903

Bioactivity

PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.

Smiles

CCc1cccc(CC)c1NC(=O)N1Cc2[nH]nc(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1

Molecular Formula

C28H35N7O2

Molecular Weight

501.62

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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