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AMG-548 hydrochloride

Product Specifications

Target

Others, Casein Kinase, p38 MAPK

Related Pathways

Stem Cells, MAPK, Others, Metabolism

Bioactivity

AMG-548 hydrochloride is a selective, orally active p38α inhibitor with a Ki value of 0.5 nM, a slight selectivity for p38β (Ki=36 nM) and a 1000-fold selectivity for p38γ and p38δ. AMG 548 hydrochloride also effectively inhibits whole blood LPS-stimulated TNFα with an IC50 value of 3 nM. AMG-548 hydrochloride directly inhibited casein kinase 1 isoforms δ and ε, which in turn inhibited Wnt signaling.

Molecular Formula

C29H28ClN5O

Molecular Weight

498.02

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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