RAF-IN-1
Product Specifications
CAS Number
2695505-82-7
Target
Raf, Others
Related Pathways
Others, MAPK
Bioactivity
RAF-IN-1 is a potent inhibitor of b/cRAF, acting on cRAF (IC50: 3.8 nM), bRAFwt (IC50: 36 nM), and bRAFV600E (IC50: 29.4 nM), and inhibiting A375 and H358 cell lines carrying the bRAFV600E mutation with a GI50 of 3.4 and 2.9 nM, respectively.
Smiles
O=C1NC2(OC=3C1=CC=C(C3)C4=CC(NC(=O)C=5C=C(C(F)(F)F)N=CC5)=CC=C4C)CCOCC2
Molecular Formula
C26H22F3N3O4
Molecular Weight
497.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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