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BRD4 Inhibitor-18

Product Specifications

CAS Number

2451219-73-9

Target

Others, Apoptosis, Epigenetic Reader Domain, c-Myc

Related Pathways

Others, Chromatin/Epigenetic, Cell Cycle/Checkpoint, Apoptosis

Bioactivity

BRD4 Inhibitor-18 is a potent BRD4 inhibitor (IC50: 110 nM) with a hydrophobic acetylcyclopentane side chain. BRD4 Inhibitor-18 significantly reduces the proliferation of MV-4-11 cells with high BRD4 levels, inhibits G0/G1 cycle activity, and promotes apoptosis. The inhibition of G0/G1 cycle activity and apoptosis were also observed.

Smiles

CN1C=2C=3C(C(=NC(CC(NC4CCCC4)=O)C2SC1=O)C5=CC=C(Cl)C=C5)=CC(OC)=CC3

Molecular Formula

C26H26ClN3O3S

Molecular Weight

496.02

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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