ALV1
Product Specifications
CAS Number
2438124-79-7
Target
Others, Interleukin, Ligand for E3 Ligase, IKZF, Molecular Glues
Related Pathways
Others, Immunology/Inflammation, PROTAC
Bioactivity
ALV1 is a potent degradation agent of Ikaros and Helios, with similar degradation activity against IKZF1/2/3. ALV1 significantly reduced the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4, and induced Helios/CRBN dimerization, which promoted IL-2 secretion.
Smiles
Cc1ccc(NC(=O)CCc2cccc(NC3=CC(=O)N(C4CCC(=O)NC4=O)C3=O)c2)cc1Cl
Molecular Formula
C25H23ClN4O5
Molecular Weight
494.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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