ALV1
Product Specifications
CAS Number
2438124-79-7
Target
Others, Interleukin, Ligand for E3 Ligase, IKZF, Molecular Glues
Related Pathways
Others, Immunology/Inflammation, PROTAC
Bioactivity
ALV1 is a potent degradation agent of Ikaros and Helios, with similar degradation activity against IKZF1/2/3. ALV1 significantly reduced the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4, and induced Helios/CRBN dimerization, which promoted IL-2 secretion.
Smiles
Cc1ccc(NC(=O)CCc2cccc(NC3=CC(=O)N(C4CCC(=O)NC4=O)C3=O)c2)cc1Cl
Molecular Formula
C25H23ClN4O5
Molecular Weight
494.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV705542 1.0 µg DNA
ZCCHC9 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)
Sign In for Pricing
View Details 
VAng-Lsx8717-50gEcoli 50 µg (E. coli)
Recombinant Clostridium Botulinum rpsP Protein (aa 1-82) (strain Kyoto / Type A2)
Sign In for Pricing
View Details