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IRAK4-IN-15

Product Specifications

CAS Number

2667681-85-6

Target

Others, IRAK

Related Pathways

NF-κB, Others, Immunology/Inflammation

Bioactivity

IRAK4-IN-15 is a selective and potent IRAK4 inhibitor (IC50: 0.002 μM) with good human PK prediction and low intrinsic clearance.IRAK4-IN-15 in combination with Acalabrutinib exhibited potent synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL.

Smiles

CN1CC2(CC(C2)N3C=C(NC4=NC5=C(C(NC(C)C)=N4)N=C(C(F)=C5)C=6C=NC(C)=NC6)C=N3)C1

Molecular Formula

C25H29FN10

Molecular Weight

488.56

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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