IRAK4-IN-15
Product Specifications
CAS Number
2667681-85-6
Target
Others, IRAK
Related Pathways
NF-κB, Others, Immunology/Inflammation
Bioactivity
IRAK4-IN-15 is a selective and potent IRAK4 inhibitor (IC50: 0.002 μM) with good human PK prediction and low intrinsic clearance.IRAK4-IN-15 in combination with Acalabrutinib exhibited potent synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL.
Smiles
CN1CC2(CC(C2)N3C=C(NC4=NC5=C(C(NC(C)C)=N4)N=C(C(F)=C5)C=6C=NC(C)=NC6)C=N3)C1
Molecular Formula
C25H29FN10
Molecular Weight
488.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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