KRAS inhibitor-14
Product Specifications
CAS Number
2230873-78-4
Target
Ras, Others, Kras
Related Pathways
GPCR/G Protein, Others, MAPK
Bioactivity
KRAS inhibitor-14 is a potent inhibitor of KRAS G12C (IC50: 0.249 μM) . KRAS inhibitor-14 exhibited p-ERK inhibition in MIA PaCA-2, A549 cells with IC50s of 1.12, >33.3 μM, respectively. KRAS inhibitor-14 has potential to be investigated in pancreatic, colorectal and lung cancers.
Smiles
FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(Cl)C(Cl)=CC(O)=C4
Molecular Formula
C20H15Cl3FN3O2S
Molecular Weight
486.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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