Simmiparib
Product Specifications
CAS Number
1551355-46-4
Target
Apoptosis|||PARP
Related Pathways
Apoptosis|||Chromatin/Epigenetic|||DNA Damage/DNA Repair
Purity
0.9951
Bioactivity
Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR) -deficient cells, thereby contributing to apoptosis.Simmiparib has been used for study Parkinson's disease, Alzheimer's disease, breast cancer, and melanoma.
Smiles
CC1CN(Cc2nnc(n12)C(F)(F)F)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F
Molecular Formula
C23H18F4N6O2
Molecular Weight
486.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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