γ-Secretase modulator 11
Product Specifications
CAS Number
2434630-29-0
Target
Others, Gamma-secretase
Related Pathways
Neuroscience, Proteases/Proteasome, Others, Stem Cells
Bioactivity
5-{8-[ (3,4'-Difluoro[1,1'-biphenyl]-4-yl) methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and brain exposure, significantly reduced brain Aβ42 levels, showed no inhibitory effect on cytochrome p450 enzymes, and demonstrated excellent anti-cognitive deficits in AD model mice.
Smiles
CC1=C(N2C(C(OCC3=C(F)C=C(C=C3)C4=CC=C(F)C=C4)=CC=C2)=N1)C=5C=CC(C(NC)=O)=NC5
Molecular Formula
C28H22F2N4O2
Molecular Weight
484.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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