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Tofacitinib

Product Specifications

CAS Number

477600-75-2

Target

Apoptosis, ROCK, JAK, Src

Related Pathways

Cell Cycle/Checkpoint, JAK/STAT signaling, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Angiogenesis, Stem Cells, Apoptosis

Purity

>99.99%

Bioactivity

Tofacitinib (Tasocitinib) is a Janus kinase inhibitor that inhibits JAK3/2/1 (IC50=1/20/112 nM) and is orally active. Tofacitinib is used for the treatment of moderate to severe rheumatoid arthritis.

Smiles

C[C@@H]1CCN(C[C@@H]1N(C)C1=C2C=CNC2=NC=N1)C(=O)CC#N

Molecular Formula

C16H20N6O

Molecular Weight

312.37

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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