Tofacitinib
Product Specifications
CAS Number
477600-75-2
Target
Apoptosis, ROCK, JAK, Src
Related Pathways
Cell Cycle/Checkpoint, JAK/STAT signaling, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Angiogenesis, Stem Cells, Apoptosis
Purity
>99.99%
Bioactivity
Tofacitinib (Tasocitinib) is a Janus kinase inhibitor that inhibits JAK3/2/1 (IC50=1/20/112 nM) and is orally active. Tofacitinib is used for the treatment of moderate to severe rheumatoid arthritis.
Smiles
C[C@@H]1CCN(C[C@@H]1N(C)C1=C2C=CNC2=NC=N1)C(=O)CC#N
Molecular Formula
C16H20N6O
Molecular Weight
312.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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