HDAC1/2 and CDK2-IN-1
Product Specifications
CAS Number
2418559-01-8
Target
Apoptosis|||Others|||HDAC|||CDK
Related Pathways
Chromatin/Epigenetic|||Apoptosis|||Others|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Bioactivity
HDAC1/2 and CDK2-IN-1 (compound 14d) are potent inhibitors of HDAC1, HDAC2, and CDK2 with IC50 values of 70.7, 23.1, and 0.80 ?M, respectively. HDAC1/2 and CDK2-IN-1 can block the cell cycle and induce apoptosis, demonstrating good anti-tumor effects in vivo.
Smiles
C(N1C=2C(=C(NC3=CC=C(C)C=C3)N=C(Cl)N2)N=C1)C4=CC=C(C(NC5=C(N)C=CC=C5)=O)C=C4
Molecular Formula
C26H22ClN7O
Molecular Weight
483.95
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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