A?-IN-1
Product Specifications
CAS Number
2766509-32-2
Target
Beta Amyloid|||Gamma-secretase
Related Pathways
Stem Cells|||Proteases/Proteasome|||Neuroscience
Purity
0.9957
Bioactivity
A?-IN-1 is a novel, potent and orally active ?-secretase modulator (GSM) . A?-IN-1 potently reduced A?42 levels with an IC 50 value of 0.091 ?M in cultured cells without inhibiting CYP3A4. A?-IN-1 shows a sustained pharmacokinetic profile.
Smiles
C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)[H])[H])(CC=C1C=5C(CC2)=NC=6C(C5C)=CC=CC6)[H])[H]
Molecular Formula
C35H49N
Molecular Weight
483.77
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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