SR12418
Product Specifications
CAS Number
1801185-08-9
Target
Autophagy, REV-ERB, IL Receptor
Related Pathways
Immunology/Inflammation, Autophagy, Metabolism
Purity
0.9996
Bioactivity
SR12418 is a specific synthetic ligand for REV-ERB, demonstrating binding affinity for both REV-ERBα (IC50 = 68 nM) and REV-ERBβ (IC50 = 119 nM) in TR-FRET assays. SR12418 inhibits IL-17A expression in EL4 cells and suppresses TH17 cell differentiation, making it suitable for studies on experimental autoimmune encephalomyelitis (EAE) and colitis.
Smiles
C(=O)(N1[C@H](COC2=CC=C(OC(C)(C)C)C=C2)CC=3C(C1)=CC=C(F)C3)C=4C5=C(C=CC4)C=CC=C5
Molecular Formula
C31H30FNO3
Molecular Weight
483.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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