HSP90-IN-13
Product Specifications
CAS Number
2446055-29-2
Target
Others|||VEGFR|||HSP|||Apoptosis|||EGFR|||Topoisomerase
Related Pathways
Cytoskeletal Signaling|||Metabolism|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Others|||DNA Damage/DNA Repair|||Angiogenesis|||Apoptosis
Bioactivity
HSP90-IN-13 (compound 5k) is a potent broad-spectrum inhibitor of HSP90 with an IC50 of 25.07 nM, exhibiting multitargeted activity against EGFR, VEGFR-2, and Topoisomerase-2. It blocks the MCF-7 cell cycle in the G2/M phase and induces apoptosis through a mitochondria-mediated pathway.
Smiles
C(N1C(SCC2=CN(N=N2)C3=CC(C(O)=O)=CC=C3)=NC=4C(C1=O)=CC(C)=CC4)C5=CC=CC=C5
Molecular Formula
C26H21N5O3S
Molecular Weight
483.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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