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HSP90-IN-13

Product Specifications

CAS Number

2446055-29-2

Target

Others|||VEGFR|||HSP|||Apoptosis|||EGFR|||Topoisomerase

Related Pathways

Cytoskeletal Signaling|||Metabolism|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Others|||DNA Damage/DNA Repair|||Angiogenesis|||Apoptosis

Bioactivity

HSP90-IN-13 (compound 5k) is a potent broad-spectrum inhibitor of HSP90 with an IC50 of 25.07 nM, exhibiting multitargeted activity against EGFR, VEGFR-2, and Topoisomerase-2. It blocks the MCF-7 cell cycle in the G2/M phase and induces apoptosis through a mitochondria-mediated pathway.

Smiles

C(N1C(SCC2=CN(N=N2)C3=CC(C(O)=O)=CC=C3)=NC=4C(C1=O)=CC(C)=CC4)C5=CC=CC=C5

Molecular Formula

C26H21N5O3S

Molecular Weight

483.54

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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