OSI-027
Product Specifications
CAS Number
936890-98-1
Target
MTOR, Autophagy, DNA-PK, PI3K
Related Pathways
DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Autophagy
Purity
0.98
Bioactivity
OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. Phase 1.
Smiles
COc1cccc2=C\C(N=c12)=c1/nc(C2CCC(CC2)C(O)=O)n2NC=NC(N)=c12
Molecular Formula
C21H22N6O3
Molecular Weight
406.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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