KRAS inhibitor-13
Product Specifications
CAS Number
2230873-96-6
Target
Ras|||Kras|||Others
Related Pathways
GPCR/G Protein|||MAPK|||Others
Bioactivity
KRAS inhibitor-13 (compound 5-6) is a potent inhibitor of KRAS G12C (IC50: 0.883 ?M) and demonstrates a p-ERK inhibitory effect in MIA PaCA-2 and A549 cells with IC50 values of 5.9 ?M and >100 ?M respectively. KRAS inhibitor-13 has potential applications in pancreatic, colorectal, and lung cancer studies.
Smiles
C(C=C)(=O)N1[C@@]2([C@@](N(C2)C3=C4C(=NS3)C(F)=C(C(Cl)=C4)C=5C6=C(C=C(O)C5)C=CC=C6)(CC1)[H])[H]
Molecular Formula
C25H19ClFN3O2S
Molecular Weight
479.95
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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