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APJ receptor agonist 5

Product Specifications

CAS Number

2135514-20-2

Target

Others|||Apelin receptor

Related Pathways

Others|||GPCR/G Protein

Bioactivity

APJ receptor agonist 5 (compound 3) is a potent and orally active apelin receptor (APJ) agonist (EC 50: 0.4 nM) with excellent pharmacokinetic profiles in rodent heart failure (HF) models and an acceptable safety profile in preclinical toxicology studies, improving cardiac function and useful for HF disease research.

Smiles

C(OCC)C=1N(C(O)=C(C(=O)N2C[C@H](CC2)C3=CC=CC=C3)C(=O)N1)C4=C(OC)C=CC=C4OC

Molecular Formula

C26H29N3O6

Molecular Weight

479.52

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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