ZLMT-12
Product Specifications
Target
Cholinesterase (ChE) |||Apoptosis|||Others|||CDK
Related Pathways
Apoptosis|||Others|||Neuroscience|||Cell Cycle/Checkpoint
Bioactivity
ZLMT-12 (compound 35) is a tacrine derivative and a potent inhibitor of CDK2 (IC50: 0.011 ?M) and CDK9 (IC50: 0.002 ?M) . ZLMT-12 weakly inhibits AChE (IC50: 19.023 ?M) and BuChE (IC50: 2.768 ?M) . ZLMT-12 has anti-proliferative activity and low cytotoxicity. ZLMT-12 blocks the cell cycle in S-phase and G2/M-phase and induces apoptosis.
Molecular Formula
C26H31ClN6O
Molecular Weight
479.02
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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