IHMT-TRK-284
Product Specifications
CAS Number
2416844-79-4
Target
PDGFR|||c-Kit|||Others|||c-Fms|||Apoptosis|||Trk receptor|||Bcr-Abl
Related Pathways
Others|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||Angiogenesis|||Apoptosis
Bioactivity
IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor with IC50 values of 10.5 nM for TRKA, 0.7 nM for TRKB, and 2.6 nM for TRKC. The compound demonstrates good selectivity within the kinase group and exhibits significant anti-tumor efficacy in vivo.
Smiles
C(=C/C1=CC=CC=N1)\C=2C=3C(=CC(=CC3)C=4SC(NC(CN5CCN(C)CC5)=O)=NC4C)NN2
Molecular Formula
C25H27N7OS
Molecular Weight
473.59
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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