CDK6/PIM1-IN-1
Product Specifications
CAS Number
2677026-14-9
Target
Others, Apoptosis, Pim, CDK
Related Pathways
JAK/STAT signaling, Apoptosis, Chromatin/Epigenetic, Others, Cell Cycle/Checkpoint
Bioactivity
CDK6/PIM1-IN-1 is a balanced, potent dual inhibitor of CDK6 (IC50: 39 nM) and PIM1 (IC50: 88 nM), also showing inhibitory activity on CDK4 (IC50: 3.6 nM) . It significantly inhibits the proliferation of acute myeloid leukemia (AML) cells, arrests the cell cycle in G1 phase, induces cell apoptosis, and demonstrates anti-AML activity.
Smiles
N(CC)(CC)C1=NC2=C(C=CC(=C2)C3=NC(NC4=CC=C(C=N4)N5CCNCC5)=NC=C3F)N=C1
Molecular Formula
C25H28FN9
Molecular Weight
473.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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