EGFR-IN-45
Product Specifications
Target
EGFR, Apoptosis, Others, Topoisomerase, CDK
Related Pathways
Cell Cycle/Checkpoint, Others, Tyrosine Kinase/Adaptors, Angiogenesis, DNA Damage/DNA Repair, JAK/STAT signaling, Apoptosis
Bioactivity
EGFR-IN-45 is a potent pan-inhibitor of the epidermal growth factor receptor (EGFR) with an IC50 of 0.4 μM and also targets CDK2 with an IC50 of 1.6 μM. It inhibits topoisomerases Topo I and Topo II, blocks the cancer cell cycle in the pre-G1 phase, and induces apoptosis.
Molecular Formula
C28H23N7O
Molecular Weight
473.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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