GNF2133 hydrochloride
Product Specifications
CAS Number
2561414-57-9
Target
DYRK|||Others
Related Pathways
Tyrosine Kinase/Adaptors|||Cell Cycle/Checkpoint|||Others
Bioactivity
GNF2133 hydrochloride is a selective, effective, and orally active DYRK1A inhibitor, able to act on DYRK1A (IC50: 0.0062 ?M) and GSK3? (IC50> 50 ?M) ; GNF2133 hydrochloride showed good proliferative ability and efficacy in rat and human primary ? cells. GNF2133 hydrochloride significantly improved glucose processing ability and increased insulin secretion. GNF2133 hydrochloride has the potential to study type 1 diabetes.
Smiles
Cl.CCN1CCN(CC1)C(=O)Nc1cc(ccn1)-c1cn(C2CCOCC2)c2cnccc12
Molecular Formula
C24H31ClN6O2
Molecular Weight
471
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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