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CCT128930 hydrochloride

Product Specifications

CAS Number

2453324-32-6

Target

Apoptosis, Akt, Autophagy, mTOR, PKA

Related Pathways

Apoptosis, PI3K/Akt/mTOR signaling, Autophagy, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling

Purity

0.9975

Bioactivity

CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50: 168 nM) through the targeting of Met282 of AKT, as well as 20-fold selectivity over p70S6K (IC50: 120 nM) .

Smiles

Cl.NC1(Cc2ccc(Cl)cc2)CCN(CC1)c1ncnc2[nH]ccc12

Molecular Formula

C18H21Cl2N5

Molecular Weight

378.3

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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