CCT128930 hydrochloride
Product Specifications
CAS Number
2453324-32-6
Target
Apoptosis|||Akt|||Autophagy|||mTOR|||PKA
Related Pathways
Apoptosis|||PI3K/Akt/mTOR signaling|||Autophagy|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling
Purity
0.9975
Bioactivity
CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50: 168 nM) through the targeting of Met282 of AKT, as well as 20-fold selectivity over p70S6K (IC50: 120 nM) .
Smiles
Cl.NC1(Cc2ccc(Cl)cc2)CCN(CC1)c1ncnc2[nH]ccc12
Molecular Formula
C18H21Cl2N5
Molecular Weight
378.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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