Henatinib
Product Specifications
CAS Number
1239269-51-2
Target
PDGFR, c-Kit, Others, VEGFR
Related Pathways
Others, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
Henatinib is an orally active small molecule multi-kinase inhibitor with broad antitumour effects. henatinib inhibits the activity of VEGFR-2 (IC50: 0.6 nM), c-kit (IC50: 3.3 nM), PDGFR (IC50: 41.5 nM) . henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signalling pathways in human umbilical vein endothelial cells (HUVECs) . Henatinib significantly inhibited VEGFR-2 phosphorylation and its downstream signaling pathway in human umbilical vein endothelial cells (HUVECs) .
Smiles
C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C4=C(N3)CCCN(C[C@@H](CN5CCOCC5)O)C4=O
Molecular Formula
C25H29FN4O4
Molecular Weight
468.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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TRV-0029525 96 Tests
Multiplex Assay Kit for Tyrosine Kinase, Non Receptor 2 (TNK2), etc. by FLIA (Flow Luminescence Immunoassay)
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