Tosedostat
Product Specifications
CAS Number
238750-77-1
Target
AChR, Aminopeptidase
Related Pathways
Metabolism, Neuroscience
Purity
0.9984
Bioactivity
Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Intracellularly converted into the poorly membrane-permeable active metabolite (CHR-79888), it inhibits puromycin-sensitive aminopeptidase (PuSA) and leukotriene A4 (LTA4) hydrolase. This inhibition in tumor cells may lead to amino acid deprivation, suppressed protein synthesis, increased proapoptotic protein Noxa levels, and ultimately, cell death.
Smiles
CC(C)C[C@H]([C@H](O)C(=O)NO)C(=O)N[C@H](C(=O)OC1CCCC1)c1ccccc1
Molecular Formula
C21H30N2O6
Molecular Weight
406.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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