10-Formyl-5,8-dideazafolic acid
Product Specifications
CAS Number
61038-31-1
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Purity
0.9604
Bioactivity
10-Formyl-5,8-dideazafolic acid (CB3717) is a water-soluble analog of folic acid, also known as folate. Folate is a member of the B-vitamin family, which plays a supporting role in a number of key biochemical reactions in the body, including RNA and DNA synthesis. Made up of pteridine, para-aminobenzoic acid, and glutamate, 10-Formyl-5,8-dideazafolic acid is a compound that inhibits de novo folate metabolism. It induces cell cycle arrest at phase G (1) -S, disrupts repair of cells damaged by radiation, and induces apoptosis.
Smiles
Nc1nc(=O)c2cc(CN(C=O)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)ccc2[nH]1
Molecular Formula
C22H21N5O7
Molecular Weight
467.43
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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