KRAS inhibitor-17
Product Specifications
CAS Number
2230873-65-9
Target
Ras, Others, Kras
Related Pathways
GPCR/G Protein, Others, MAPK
Bioactivity
KRAS inhibitor-17 (compound 3-9) is a potent inhibitor of KRAS G12C with an IC50 of 3.37 μM. It exhibits p-ERK inhibition with an IC50 of 9.25 μM in MIA PaCA-2 cells and greater than 33.3 μM in A549 cells. KRAS inhibitor-17 has potential applications in the study of pancreatic, colorectal, and lung cancers.
Smiles
FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=CC(OC)=CC=C4Cl
Molecular Formula
C21H18Cl2FN3O2S
Molecular Weight
466.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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