Pactimibe sulfate
Product Specifications
CAS Number
608510-47-0
Target
Others, Acyltransferase
Related Pathways
Others, Metabolism
Bioactivity
Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor, acting on ACAT1 (IC50: 4.9 μM) and ACAT2 (IC50: 3.0 μM) . It inhibits oleoyl-CoA non-competitively (Ki: 5.6 μM) and significantly inhibits cholesterol ester formation (IC50: 6.7 μM) . Pactimibe sulfate reduces plasma cholesterol activity and has anti-atherogenic potential.
Smiles
OS(O)(=O)=O.CCCCCCCCN1CCc2c1c(NC(=O)C(C)(C)C)c(C)c(CC(O)=O)c2C.CCCCCCCCN1CCc2c1c(NC(=O)C(C)(C)C)c(C)c(CC(O)=O)c2C
Molecular Formula
C50H82N4O10S
Molecular Weight
931.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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