RAF265
Product Specifications
CAS Number
927880-90-8
Target
VEGFR, Apoptosis, Raf, Autophagy
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis, Autophagy, MAPK
Purity
0.9956
Bioactivity
RAF265 (CHIR-265) (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. Phase 2.
Smiles
Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12
Molecular Formula
C24H16F6N6O
Molecular Weight
518.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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