GEM144
Product Specifications
CAS Number
2487526-28-1
Target
Apoptosis, Others, DNA/RNA Synthesis, HDAC
Related Pathways
Others, Chromatin/Epigenetic, Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Apoptosis
Bioactivity
GEM144 is a potent, orally active dual inhibitor of DNA polymerase α (POLA1) and HDAC 11. GEM144 induces p53 acetylation, activates p21, blocks the cell cycle in G1/S phase and induces apoptosis.
Smiles
O(C(C(NO)=O)C)C1=C(C23CC4CC(C2)CC(C3)C4)C=C(C=C1)C5=CC=C(/C=C/C(O)=O)C=C5
Molecular Formula
C28H31NO5
Molecular Weight
461.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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