TAS-117 hydrochloride
Product Specifications
Target
Others|||Akt|||Apoptosis|||Autophagy
Related Pathways
PI3K/Akt/mTOR signaling|||Autophagy|||Others|||Cytoskeletal Signaling|||Apoptosis
Bioactivity
TAS-117 hydrochloride is a selective, potent, orally active allosteric Akt inhibitor, acting on Akt1 (IC50: 4.8 nM), Akt2 (IC50: 1.6 nM) and Akt3 (IC50: 44 nM) . TAS-117 hydrochloride stimulates anti-myeloma activity, enhances lethal endoplasmic reticulum stress induced by proteasome inhibition, and can induce apoptosis and autophagy.
Molecular Formula
C26H25ClN4O2
Molecular Weight
460.96
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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