NDI-034858
Product Specifications
CAS Number
2272904-53-5
Target
Tyrosine Kinases, JAK, IL Receptor
Related Pathways
Immunology/Inflammation, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, Stem Cells
Purity
>99.99%
Bioactivity
NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23.
Smiles
CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CC[C@H]1OC
Molecular Formula
C23H24N8O3
Molecular Weight
460.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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