Tanespimycin
Product Specifications
CAS Number
75747-14-7
Target
Autophagy, Mitophagy, Apoptosis, HSP, Antibiotic, Antibacterial
Related Pathways
Microbiology/Virology, Autophagy, Cytoskeletal Signaling, Apoptosis, Metabolism
Purity
0.9983
Bioactivity
Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1 and decreases STK38 kinase activity. Tanespimycin also downregulated stk38 gene expression.
Smiles
CO[C@H]1C[C@H](C)CC2=C(NCC=C)C(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
Molecular Formula
C31H43N3O8
Molecular Weight
585.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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