MtTMPK-IN-3
Product Specifications
CAS Number
2799607-80-8
Target
Antibacterial, Others, DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Others, Microbiology/Virology, Cell Cycle/Checkpoint
Bioactivity
MtTMPK-IN-3 (compound 25) is a potent inhibitor of Mycobacterium tuberculosis thymidylate kinase (MtTMPK) with an IC50 value of 0.12 μM. It also exhibits inhibitory activity against Mtb H37Rv with a MIC of 12.5 μM and shows cytotoxicity in MRC-5 human fibroblast cells (EC50 = 12.5 μM) . This compound is useful for tuberculosis research [1].
Smiles
O=C1N(C2CCN(CC3=CC(OC4=CC(Cl)=CC(Cl)=C4)=CC=C3)CC2)C=C(C)C(=O)N1
Molecular Formula
C23H23Cl2N3O3
Molecular Weight
460.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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