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YM-341619

Product Specifications

CAS Number

643082-52-4

Target

Others, STAT

Related Pathways

Others, JAK/STAT signaling, Stem Cells

Bioactivity

YM-341619 (AS1617612) is a potent, orally active STAT6 inhibitor (IC50: 0.70 nM) that inhibits IL-4-induced Th2 differentiation in mouse splenic T cells with an IC50 value of 0.28 nM, without affecting Th1 cell differentiation. YM-341619 holds potential for research into allergic diseases, such as allergic asthma.

Smiles

NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1c(F)ccc(F)c1F

Molecular Formula

C22H21F3N6O2

Molecular Weight

458.44

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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