HOIPIN-8 sodium
Product Specifications
CAS Number
2519537-70-1
Target
IκB/IKK, E1/E2/E3 Enzyme
Related Pathways
Ubiquitination, NF-κB
Purity
0.9734
Bioactivity
HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-α-mediated NF-κB activation compared to HOIPIN-1. HOIPIN-8 is a promising tool to explore cellular functions of LUBAC.
Smiles
O=C(C1=CC=C(C2=CN(C)N=C2)C=C1/C=C/C(C3=C(C=C(C4=CNN=C4)C=C3F)F)=O)[O-].[Na+]
Molecular Formula
C23H15F2N4NaO3
Molecular Weight
456.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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